Due to an oversight in the preparation of this Review article, the authors inadvertently included a “rat” model for “Complete LAD occlusion” in Table 1 . Findings on “Japanese encephalitis” were erroneously attributed to reference 8 but are unpublished observations. Table 1 was modified to reflect those changes and the corrected version is included below. That authors apologize for these errors and assert that they make no difference to the line of discussion of this review.
Table 1.
IMP Efficacy in Severe Inflammation Models.
| Condition | Animal model | Species | Outcome | Refs |
|---|---|---|---|---|
| Acute myocardial infarction | Temporary LAD occlusion Complete LAD occlusion |
Mouse Mouse |
Reduced inflammation, reduced infarct size Increased function |
[8] |
| Kidney ischemia | Temporary renal artery occlusion | Mouse | Reduced tubular necrosis and increased function | [8] |
| Stroke | Temporary carotid artery | Mouse | Reduced inflammation | Unpublished |
| MS relapse | EAE SJL (relapsing–remitting) EAE C57BL/6 (progressive disease) |
Mouse Mouse |
Reduced symptoms, reduced inflammation and demyelination | [8] |
| IBD | DSS colitis | Mouse | Reduced symptoms, reduced inflammation, rapid recovery of the colon | [8] |
| Acute encephalitis syndrome | WNV encephalitis Japanese encephalitis |
Mouse Mouse |
Increased survival Increased survival |
[8] Unpublished |
| Spinal cord injury | Spinal cord crush | Mouse | Increased mobility, reduced inflammation | Unpublished |