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. Author manuscript; available in PMC: 2022 Sep 14.
Published in final edited form as: Immunity. 2021 Aug 2;54(9):1948–1960.e5. doi: 10.1016/j.immuni.2021.07.001

Figure 1. Adar P195A mice model the most common Aicardi-Goutieres Syndrome mutation.

Figure 1.

(A) Schematic of the structure of ADAR1 protein, and the location of the P195A mutation. Zα, Zβ, = Z-DNA binding domains, NES = Nuclear export signal, NLS = nuclear localization signal.

(B) Percentage of mice of the indicated genotype from intercrosses of AdarP195A/+ mice. (n=140 pups)

(C) Survival of Adar+/+ (n=23), AdarP195A/+ (n=47), AdarP195A/P195A (n=48) mice.

(D) Weights of mice at 23 days of age. Adar+/+ (n= 6F,12M), AdarP195A/+ (n= 13F,14M), AdarP195A/P195A (n= 8F, 9M). Bar represents the mean. See also Figure S1.