ENGINEERING, APPLIED BIOLOGICAL SCIENCES Correction for “Regenerative and durable small-diameter graft as an arterial conduit,” by Morgan B. Elliott, Brian Ginn, Takuma Fukunishi, Djahida Bedja, Abhilash Suresh, Theresa Chen, Takahiro Inoue, Harry C. Dietz, Lakshmi Santhanam, Hai-Quan Mao, Narutoshi Hibino, and Sharon Gerecht, which was first published June 10, 2019; 10.1073/pnas.1905966116 (Proc. Natl. Acad. Sci. U.S.A. 116, 12710–12719).
The authors note that the image shown in Fig. 1D, ii is an inadvertent duplication of an image that was published previously (1). The authors have provided a revised figure that includes the correct image for ii in Fig. 1D. The corrected figure and its legend appear below. The authors confirm that this change does not alter the interpretation of data or conclusions of the study. The online version has been corrected.
Fig. 1.
Fabrication of hollow fibrin hydrogel microfiber tubes. Workflow begins with (A) fibrin hydrogel microfibers being spun into a sheet by rastering the landing position of the biopolymer jet on a rotating collection solution. (B) Sheets are collected by placing a PTFE-coated mandrel on the resultant hydrogel sheet either perpendicular or parallel to the fiber orientation. (C) Sheets are then (i) wrapped, and (ii) the PTFE-coated mandrel is removed after dehydration, (iii) yielding hollow fibrin tubes with circumferential (Left) or longitudinal (Right) alignment. (D) Representative SEM micrographs of (i) circumferentially aligned hollow tube and (ii) a stretch-dried, longitudinally aligned fibrin fiber bundle. Quantification of (iii) longitudinally aligned fibrin microfiber orientation and (iv) orientation distribution for grafts dehydrated via graded EtOH and lyophilization (Lyo) treatments relative to the longitudinal graft axis (0°). (Scale bars: i, 200 µm; ii, 40 µm.) (E) Representative longitudinal and cross-section SEM micrographs of (i and ii) Lyo-treated and (iii and iv) EtOH-treated longitudinally aligned hollow tubes. (Scale bar: 400 µm.) (F) Mechanical properties, including (i) elastic modulus, (ii) axial STF, (iii) axial UTS, (iv) toughness, and (v) outer diameter of fibrin tubes dried using the Lyo and EtOH treatments (n = 3–5). *P < 0.05; ****P < 0.0001.
1. S. Zhang et al., Creating polymer hydrogel microfibres with internal alignment via electrical and mechanical stretching. Biomaterials 35, 3243–3251 (2014).