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[Preprint]. 2021 Sep 14:arXiv:2109.06377v4. Originally published 2021 Sep 14. [Version 4]

PMC8452105.1; 2021 Sep 14
PMC8452105.3; 2021 Sep 14
PMC8452105.4; 2021 Sep 14

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Figure 1. — The workflow of the ASGARD pipeline. Diseased and normal cells are paired according to “anchor” genes that are expressed consistently between the two types of cells. The differentially expressed (DE) genes are identified between diseased and normal cells, either within a cluster or within a cell type. Using the consistent DE genes as the input, potential drugs that significantly reverse the pattern of DE genes are identified, using the Kolmogorov–Smirnov (K-S) test with Benjamini-Hochberg (BH) false discovery rate (FDR) adjustment. Next ASGARD estimates and ranks the drug scores for single drugs, by targeting specific cell cluster(s) or all cell clusters.