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. 2021 May 24;16(15):2366–2374. doi: 10.1002/cmdc.202100118

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© 2021 The Authors. ChemMedChem published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Isothermal titration calorimetry (ITC) confirmed binding of 8 and 19 to the recombinant human FXR LBD^[29] and to recombinant human LTA4H.^[30] 1:1 binding was assumed.