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Selectivity of 8 and 19 over related targets within the arachidonic acid cascade.
|
|
8 |
19 |
|---|---|---|
|
sEH inhibition[a] |
6±1 % inhibition at 100 μM |
IC50=68±2 μM |
[a] sEH inhibition was determined on recombinant human sEH protein using (3‐phenyloxiranyl)acetic acid cyano‐(6‐methoxynaphthalen‐2‐yl)methyl ester (PHOME) as fluorogenic substrate[31]. Data are the mean±S.E.M., n=3.
