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. 2020 Dec 12;70(10):1872–1883. doi: 10.1136/gutjnl-2020-322468

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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OGA enzymatic functions are required for bacterial OGAs’ protective effects on DSS-induced colitis. (A) Schematic outline of the DSS-colitis model and the treatment approach. (B) Immunoblot analysis of O-GlcNAc levels in colonic tissue lysates of mice. (C–F) Disease severity of DSS-colitis mice treated with wild type enzymes or their active sites mutants: body weight change (C), histology manifestation on H&E staining (D), scale bar: 200 µm, colon length (E) and inflammation score (F). (G–J) Proinflammatory cytokines in colonic tissue lysates. Data represent the mean of three repeats per group with the SD; *P<0.05, **P<0.01, ***P<0.001. DSS, dextran sulfate sodium; IL, interleukin; OGA, O-GlcNAcase; TNF, tumour necrosis factor.