Figure 6.

Key immunotherapy target genes overexpressed in the MLP-1 subtype. (A–E) Expression (log₂) levels of inhibitory checkpoint (PDL1, PD-L2, LAG3, IDO1 and C10orf54) genes in the training cohort. (F). T cell-inflamed GEP (to predict potential response to anti-PD1 treatment) for the training cohort. Expression (mean) data for 14 of the 18 relevant genes were available. FDR (after multiple testing correction) or p value computed by Kruskal-Wallis test. FDR, false discovery rate; GEP, gene expression profile; MLP, metastasis-like primary.