Figure 6.

ISG induction in Adar1^mZα/mZα mice is MAVS dependent

(A and B) Levels of the indicated mRNAs were analyzed using qRT-PCR in RNA samples extracted from tissues of WT and Adar1^mZα/mZα animals that were either MAVS sufficient or deficient. Data are shown relative to Gapdh.

(C) Mice of the indicated genotypes were infected intranasally with 0.04 HAU of IAV strain A/X-31. Body weight was monitored daily and is shown as a percentage of starting body weight.

In (A) and (B), each dot represents an individual mouse, and pooled data from three independent experiments are shown (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, and ^∗∗∗∗p < 0.0001, unpaired t test). In (C), data from two independent experiments including a total of 10–12 mice per genotype were pooled (mean with SD).