Figure 6:

Microorganisms influence the expression of immune-related genes in the uterus. (a) Hierarchical clustering and (b) pairwise Pearson correlations of 12 samples using transcriptional profiles. The error bars indicate the standard error values in the corresponding group, respectively. (c) Differentially expressed genes between groups with high and low egg production. Eight well-documented inflammatory markers are labeled. (d) Comparison of expression changes of 8 inflammatory markers in the uterus between groups with high and low egg production by a q-PCR approach. Data are shown as the mean ± standard error. ^*P < 0.05. (e) Top 20 functional categories enriched for 739 genes that were significantly downregulated in the high egg production group. The enrichment analysis was performed using the Metascape tool (see Methods). GO-BP: biological process (blue); GO-MF: molecular function (yellow).