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. 2021 Sep 18;26(18):5677. doi: 10.3390/molecules26185677

Scheme 8.

Scheme 8

Synthetic route to 14-methoxy, 5-benzyl substituted 21. Reaction scheme for the synthesis of 5-benzyl substituted morphinans. Reagents and conditions: (a) NaH, (CH3O)2SO2, DMF, 0 °C; (b) 10% Pd/C, H2, MeOH, 30 psi, r.t.; (c) 48% HBr, reflux.