How Sleep Affects Daytime Functioning: The Latest Insights from Different Patient and Age Groups

Sleep problems can have a major impact on daytime functioning across all domains (i.e., cognitive, affective and physical). It can affect attention, concentration and higher cognitive functions, such as working memory [1], as well as the levels of stress, anxiety and depression [2]. The prevalence of sleep problems has increased exponentially since the COVID-19 outbreak [3,4,5], underlining the urgency to prevent and treat sleep problems, in order to preserve long-term physical and mental health [6].

In this special issue, we address the important topic of sleep-related daytime functioning with publications on a variety of sleep disorders, their pathophysiological mechanisms, comorbid conditions and daytime consequences. First, the paper by Reddy and Van der Werf sheds light on the important function of sleep, during which replenishing and cleansing of the brain occurs by enhancing glymphatic clearance. Toxic effects on brain functioning that occur in the context of, for example, Alzheimer’s disease, can be limited by this clearance. The paper summarizes how lifestyle choices during the day and night, such as stress reduction and Omega-3 consumption, can further enhance this glymphatic clearance [7].

More sleep-related neural mechanisms are addressed in the manuscript by Gool et al. [8], in which they show that narcolepsy patients, who suffer from uncontrollable sleep fits during daytime, have problems performing attention tasks in a dose response manner with increasing complexity. This is accompanied by a lower activity in those brain regions important for stabilizing attention levels and inhibiting error-related motor activity, suggestive of affected executive functioning in narcolepsy patients [8].

Affected sustained attention is also reported by Angelelli et al., who investigated those with obstructive sleep apnea (OSA-breathing difficulties during the night), in relation to attention problems and sleepiness during daytime. Interestingly, OSA patients were shown to have difficulties in specific aspects of attention processes. The authors emphasize that measuring reaction time alone does not suffice in describing the variety of these problems, which include selective attention and performance stability [9].

The manuscript by Hill et al. then shows that apnea treatment in adults with Down syndrome, not only reduced sleepiness, but also resulted in reductions in anxiety and depression, while intelligence and global health scores also improved [10]. The findings by Angelelli et al. and Hull et al. underline the importance of investigating and treating sleep apnea thoroughly, in order to improve daytime functioning, particularly in vulnerable populations.

Focusing on a different sleep disorder, namely insomnia, the work by Bickly et al. proposes a new instrument to measure how this condition affects different types of daytime activities, such as work, care for children and physical exercise. The researchers show that while insomnia patients participate in most daytime activities, they report that it takes them more effort and that sleep affects their participation negatively [11], which warrants timely intervention for this chronic limiting condition.

The manuscripts by Kölbel et al., Bacaro et al. and Mughal et al. address different aspects of the vital topic of sleep problems in children. In young children from six months to three years, Bacaro et al. show that daytime naps and night-time sleep duration are lower than formal health guidelines suggest. These guidelines stipulate that period of time before falling asleep is inversely related to positive emotions, and that daytime naps play an important role in emotional regulation in toddlers [12]. Kölbel et al. show that different sleep disorders are prevalent in children and young adults suffering from sickle cell anemia (4–23 years of age), causing daytime sleepiness [13]. By comparing groups of 6-to-12-year olds with, and without, autism or fetal alcohol syndrome, Mughal et al. show that in all participants, cognitive performance was related to sleep quality, and that particularly those children with autism or fetal alcohol syndrome suffered from multiple sleep problems [14].

In summary, the importance of investigating daytime consequences of sleep problems is emphasized by a collection of excellent manuscripts highlighting different sleep disorders, how they affect daytime cognitive functioning and sleepiness, how they are affected in vulnerable populations and what pathophysiological mechanism underlie them. These reports warrant future research on the effects of sleep treatment on cognitive, affective and physical daytime functions, as well as global health.

Funding

This research received no external funding.

Conflicts of Interest

The authors declare no conflict of interest.