Table 2.

Population data for IV, oral, intranasal, and rectal administration of diazepam in the adult population.

No.	Population	No. of Subjects	Dose (mg)	Dosage Form	Age (Years)	Weight (kg)	Female Proportion	Ref.
IV
1	Healthy	9	2	IV solution	20−30	58−80	0	[46]
2	Healthy	8	5	IV solution	Mean 28.3	-	0.33	[47]
3	Healthy	24	5	IV solution	18−45	Mean 71.8	0.2	[48]
4	Healthy	20	7.5	IV solution	Mean 28.8	Mean 72.6	0	[49]
5	Healthy	9	1	IV solution	18−25	58−70	0.33	[15]
6	Healthy	1	10	IV solution	26−37	60−85	0.2	[50]
Oral
7	Healthy	11	2	-	19−35	-	0.27	[51]
8	Healthy	11	5	-	19−35	-	0.27	[51]
9	Healthy	48	10	Tablets	18−44	59.1−95	0	[52]
10	Healthy	11	10	-	19−35	-	0.27	[51]
11	Healthy	9	10	Tablet	18−25	58−70	0.33	[15]
Intranasal
12	Healthy	9	2	Solution	20−30	58–80	0	[46]
13	Healthy	8	5	Supersaturated solution	Mean 28.3	-	0.33	[47]
14	Healthy	24	10	Solution	18−45	Mean 71.8	0.2	[48]
15	Healthy	24	10	Suspension	18−45	Mean 71.8	0.2	[48]
16	Healthy	8	10	Supersaturated solution	Mean 28.3	-	0.33	[47]
17	Healthy	1	10	Solution	26−37	60−85	0.2	[50]
Rectal
18	Healthy	9	10	Solution	18−25	58−70	0.33	[15]
19	Healthy	9	10	Suppository	18−25	58−70	0.33	[15]
19	Healthy	20	15	Gel	Mean 28.8	Mean 173.9	0	[49]