Table 3.

Observed and predicted values of PK parameters after IV, oral, intranasal, and rectal routes of administration.

	Dose (mg)	Cmax (ng/mL)		Ratio	AUC0–t (ng.h/mL)		Ratio	CL (L/h)		Ratio	Ref.
		Observed	Predicted		Observed	Predicted		Observed	Predicted
IV
1	2	157.06	154.39	1.01	285.45	256.60	1.11	7.00	7.79	0.89	[46]
2	5	332.28	452.92	0.73	455.11	522.20	0.87	10.98	9.57	1.14	[47]
3	5	492.1	479.77	1.02	851.74	1305.30	0.65	5.87	3.83	1.53	[48]
4	7.5	536.44	605.14	0.88	1244	1428.08	0.87	6.27	5.46	1.14	[49]
5	10	623	586.11	1.06	3505.37	3117.92	1.12	2.85	3.2	0.89	[15]
6	10	642.95	634.13	1.01	4491.90	4364.79	1.02	2.22	2.29	0.97	[50]
Oral
1	2	62.07	63.97	0.97	330	406.55	0.81	6.06	4.91	1.23	[51]
2	5	125.24	159.95	0.78	784.19	1012.40	0.77	6.37	4.93	1.29	[51]
3	10	325	311.87	1.04	3487	2965.75	1.17	2.86	3.37	0.80	[15]
4	10	255.53	322.62	0.80	1540.28	2026.76	0.75	6.49	4.93	1.31	[51]
5	10	352	318.99	1.10	1445.96	1493.59	0.96	6.91	6.66	1.03	[52]
Intranasal
1	2	46.25	39.66	1.16	161.73	159.94	1.01	12.36	12.5	0.98	[46]
2	5	102.66	127.34	0.80	309.82	352.62	0.87	16.13	14.18	1.13	[47]
3	10	218.15	222.08	0.98	1513.78	1532.92	0.98	6.60	6.52	1.01	[48]
4	10	172.99	222.48	0.77	1084	1523.59	0.70	9.22	6.56	1.41	[48]
5	10	180.51	254.69	0.70	588.64	710.80	0.82	16.98	14.06	1.20	[47]
6	10	236.82	222.70	1.06	3558.44	3033.84	1.17	2.81	3.29	0.85	[50]
Rectal
1	10	297	224.17	1.32	3566.35	2699.95	1.32	2.80	3.70	0.75	[15]
2	10	254	229.40	1.10	3258.12	2666.01	1.22	3.06	3.75	0.81	[15]
3	15	384.86	350.74	1.09	2070.02	2028.11	1.02	7.24	7.39	0.97	[49]