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Robs/pred and AFE values of PK parameters in an adult population after IV, oral, intranasal, and rectal administration of diazepam.
| Parameters | Robs/pred | AFE |
|---|---|---|
| IV | ||
| AUC0–t | 0.94 | 0.93 |
| CL | 1.10 | 1.08 |
| Cmax | 0.96 | 0.95 |
| Oral | ||
| AUC0–t | 0.90 | 0.89 |
| CL | 1.15 | 1.13 |
| Cmax | 0.94 | 0.93 |
| Intranasal | ||
| AUC0–t | 0.93 | 0.92 |
| CL | 1.10 | 1.09 |
| Cmax | 0.92 | 0.90 |
| Rectal | ||
| AUC0–t | 1.19 | 1.18 |
| CL | 0.85 | 0.85 |
| Cmax | 1.18 | 1.17 |
