Table 4.

Precision and accuracy for edaravone bioanalysis method in rat and beagle dog matrices (n = 5).

Matrix	Intra-Batch								Inter-Batch
	Precision (CV, %)				Accuracy (%)				Precision (CV, %)				Accuracy (%)
	LLOQ	QL	QM	QH	LLOQ	QL	QM	QH	LLOQ	QL	QM	QH	LLOQ	QL	QM	QH
Rats
Plasma	8.15	6.29	2.01	3.41	106.54	107.30	108.55	109.23	5.21	5.98	1.14	1.98	106.81	104.42	108.14	107.13
Brain	12.46	5.39	1.53	6.37	100.81	94.11	102.17	99.32	6.39	2.62	1.65	2.83	108.61	96.59	102.5	102.66
Liver	7.32	6.35	1.04	0.33	110.88	98.25	97.65	94.83	7.75	2.85	4.02	2.83	106.59	100.82	101.57	97.91
Kidney	9.19	1.71	1.48	7.37	107.35	102.92	98.11	98.00	2.00	7.20	2.85	2.07	104.95	99.30	100.85	99.30
Heart	7.25	7.02	2.07	2.88	111.55	96.61	101.66	101.15	1.70	10.28	3.87	3.28	111.22	100.28	101.27	102.98
Lung	5.39	7.92	2.37	2.4	99.45	96.87	99.06	95.25	9.96	3.48	5.74	7.41	100.12	95.59	100.56	100.8
GI tract	2.72	6.26	3.12	2.67	109.85	99.38	97.69	104.59	12.08	11.28	0.23	2.01	107.25	101.87	100.97	105.42
Beagle dogs
Plasma	5.57	2.27	2.87	1.36	106.42	103.73	98.14	101.36	2.84	3.95	3.42	2.00	104.28	101.26	99.19	102.67
CSF	8.58	4.18	2.78	3.08	107.81	102.99	98.54	100.34	3.12	2.51	0.25	2.61	100.83	105.10	98.97	103.17
Urine	10.57	5.56	6.38	5.83	88.88	92.89	103.83	104.76	15.24	10.17	0.23	3.53	99.53	87.17	102.45	109.44
Feces	0.35	2.01	5.45	0.22	110.72	101.32	105.36	98.30	7.16	11.34	9.35	9.06	111.17	98.97	98.73	98.55