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. 2021 Sep 7;13(9):1419. doi: 10.3390/pharmaceutics13091419

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representative Dixon plots obtained from inhibition kinetic studies of CYP1A2-mediated phenacetin O-deethylation (A); CYP2C19-mediated S-mephenytoin 4-hydroxylation (B); CYP2E1-mediated chlorzoxazone 6-hydroxylation (C), and CYP3A-mediated nifedipine dehydrogenation (D) in the presence of different concentrations of trans-resveratrol in pooled human liver microsomes (n = 3). Each trans-resveratrol (0, 0.5, 2.0, 5.0, 20, and 50 μM) was pre-incubated with HLMs in the presence of an NADPH-generating system (30 min, 37 °C), and then an increasing concentration of phenacetin (5 (⬤), 20 (◯), and 50 μM (▼)), S-mephenytoin (20 (⬤), 40 (◯), and 100 μM (▼)), chlorzoxazone (1 (⬤), 5 (◯), and 20 μM (▼)), and nifedipine (0.2 (⬤), 1 (◯), and 5 μM (▼)) was added prior to further incubation for 10 min.