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Effect of 13-HODE-G and related compounds on human recombinant TRPV1-mediated intracellular calcium elevation. Results are shown as the mean ± SD. 1 Desensibilization was assayed using 100 nM capsaicin.
| Compound | Efficacy (% Max Response) |
Potency (EC50 in µM) |
Desensibilization 1 (IC50 in µM) |
|---|---|---|---|
| 1-AG | 58.9 ± 1.2 | 0.39 ± 0.03 | 1.1 ± 0.1 |
| 1-LG | 46.5 ± 0.9 | 0.23 ± 0.02 | 2.7 ± 0.3 |
| 13-HODE | < 10 | - | > 50 |
| 13-HODE-G | < 10 | - | > 50 |
