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Predicted targets of Curcumin and its analogues by computer-aided drug design.
| Compound | Predicted Mycobacterial Target | Reference |
|---|---|---|
| Curcumin | Universal stress protein (USP) | [53] |
| Aspartate-β-semialdehyde dehydrogenase (ASD) | [54] | |
| Dihydrodipicolinate reductase | ||
| Monoacetylcurcumin | M. tuberculosis NAD+-dependent DNA ligases (MtuLigA) | [55] |
| BRCT domain-containing DNA polymerase λ | [56] | |
| Quinolidene based monocarbonyl curcumin analogues 3e, 3h, 4a and 4e | Pantothenate synthetase (MTB PS) | [50] |
