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. 2021 Sep 15;13(9):3209. doi: 10.3390/nu13093209

Figure 2.

Figure 2

Experimental procedure and effects of LE on the clinical features of AD-like symptoms induced by DNCB in NC/Nga mice. (A) Schematic diagram of the experimental procedure for AD lesion induction and LE treatment. (B) On the last day of the 14th week of the experiment, the right ear and dorsal skin of mice representing each group were shown. (C–E) The clinical features of NC/Nga mice (C) dermatitis score, (D) ear thickness, and (E) scratching behavior were evaluated three times a week in the term of the administration of CMC, PD, and LE. The results were expressed as means ± SD (n = 6). ### p < 0.001 vs. normal (DNCB untreated group), * p < 0.05, ** p < 0.01, and *** p < 0.001 vs. DNCB (negative control; DNCB treated group), PD (positive control; prednisolone 3 mg/kg) treatment group, LE (LE 50, 100 or 200 mg/kg) treatment group, and † p < 0.05, ††† p < 0.001 vs. PD (positive control; prednisolone 3 mg/kg) treatment group.