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. 2021 Sep 15;13(9):3209. doi: 10.3390/nu13093209

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of LE on AD-related cytokines and chemokines in the serum of NC/Nga mice. (A–H) The levels of (A) IL-1β, (B) IL-6 (C) TNF-α, (D) TSLP, (E) TARC (F) MDC, (G) RANTES, and (H) MCP-1 in the serum. Serum was collected on the last day of the experiment and measured using ELISA. The results were expressed as means ± SD (n = 6). ^### p < 0.001 vs. normal (DNCB untreated group), *** p < 0.001 vs. DNCB (negative control; DNCB treated group), PD (positive control; prednisolone 3 mg/kg) treatment group, LE (LE 50, 100 or 200 mg/kg) treatment group, and ^† p < 0.05, ^†† p < 0.01, and ^††† p < 0.001 vs. PD (positive control; prednisolone 3 mg/kg) treatment group.