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. 2021 Sep 15;13(9):3209. doi: 10.3390/nu13093209

Figure 8.

Figure 8

Effect of LE on gene expression of cytokines, chemokines, and CCR4 that activate Th2 cells in dorsal skin of NC/Nga mice. Gene expression of (A) IL-25, (B) IL-33, (C) TSLP, (D) RANTES, (E) TARC, (F) MDC, and (G) CCR4. Total RNA was extracted from the dorsal skin of NC/Nga mice and normalized to GAPDH. The results were expressed as means ± SD (n = 6). ### p < 0.001 vs. normal (DNCB untreated group), * p < 0.05, ** p < 0.01, and *** p < 0.001 vs. DNCB (negative control; DNCB treated group), PD (positive control; prednisolone 3 mg/kg) treatment group, LE (LE 50, 100 or 200 mg/kg) treatment group, and † p < 0.05, †† p < 0.01 vs. PD (positive control; prednisolone 3 mg/kg) treatment group.