Figure 7.

More robust regeneration after CAR-DCN treatment of mdxD2 mice. These representative Masson’s Trichrome pictures are from CAR-DCN, mCAR-DCN, or control three week treated mice. The vastus lateralis of the quadriceps was imaged at original magnification of 20×. Late stage regenerative fibers, identified by central nuclei and almost normal size (arrowheads); necrotic fibers are the cells with many gaps (arrows); immune infiltrate identified with closely packed nuclei (asterisks); and fibrotic areas identified by the blue staining (number sign) are indicated in the images. The mCAR-DCN treated muscle had more pathology as revealed by fewer normally sized muscles, more immune cells between muscle cells than in the CAR-DCN treated mice, and the distinctive presence of fibrotic areas. Original magnification 10×.