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. 2021 Sep 24;72:103590. doi: 10.1016/j.ebiom.2021.103590

Table 4.

Characteristics of patients with and without SPMS-conversion.

No conversion SPMS conversion P-value
N 169 27
Age at diagnosis 30.8 (24.7-40.6) 36.1 (26.4-45.1) 0.194
NfL (Baseline) pg/ml 7.9 (4.7-12.9) 9.2 (4.5-13.7) 0.657
Age at Baseline 33.1 (26.5-42.3) 42.6 (34.3-48.9) 0.001
NfL (FU) pg/ml 6.9 (5.0-9.2) 10.4 (6.9-17.6) <0.001
sNfL FU/BL ratio 0.96 (0.75-1.23) 1.16 (0.89-1.70) 0.011
Age at FU 39.1 (32.6-48.5) 51.1 (41.0-55.6) <0.001
Female 116 (68.6) 21 (77.8) 0.336
Disease course at Baseline 0.450
  • -

    CIS

 3 (1.8) 1 (3.7)
  • -

    RRMS

 166 (98.2) 26 (96.3)
Smoking 43 (35.8) 9 (39.1) 0.763
  • -

    Pack Years

 15.60 (±12.2) 18.25 (±14.08) 0.582
OCB positive 148 (87.6) 20 (74.1) 0.063
Relapses
  • -

    3 months prior Baseline

 74 (43.8) 7 (8.6) 0.080
  • -

    12 months prior Baseline

 108 (64.9) 10 (37.0) 0.008
  • -

    3 months prior follow-up

 8 (4.7) 0 (0) 0.248
EDSS
  • -

    Baseline

 1 (0-1.5) 2.5 (1.0-3.5) <0.001
  • -

    Follow-Up

 1 (0-2.0) 5.0 (3.5-6.0) <0.001
Disease duration (years) 7.4 (6.0-9.2) 10.4 (8.2-20.2) <0.001
MRI Baseline
Gd-enhancement 48 (28.4) 8 (29.6) 0.319
Gd lesion number 0.67 (±1.80) 1.62 (±3.86) 0.231
T2 lesion number 15.40 (±12.15) 19.52 (±15.48) 0.129
MRI FU
  • -

    Gd-enhancement

 6 (3.6) 0 (0) 1.000
  • -

    Gd lesion number

 0.12 (±0.78) 0 (0) 0.877
  • -

    New T1 lesion

 33 (19.5) 6 (22.2) 0.796
  • -

    New T1 lesion number

 0.54 (±1.42) 0.62 (±1.16) 0.813
DMT at FU 132 (78.1) 18 (69.2) 0.317
No. of DMTs initiated 2 (1-3) 3 (2-4) 0.005
Disease course FU
  • -

    CIS

 2 (1.2) 0 (0)
  • -

    RRMS

 167 (98.8) 0 (0)
  • -

    SPMS

 0 (0) 27 (100.0)
Relapse-free progression <0.001
  • -

    No

 156 (96.3) 6 (3.7)
  • -

    Yes

 13 (38.2) 21 (61.8)
Relapse activity - FU
  • -

    No of Relapses last 5 years

 0.90 (±1.67) 0.88 (±1.07) 0.962
  • -

    No of Relapses last year

 0.17 (±0.491) 0 (±0) 0.017

Data is presented as number (percentages), median (interquartile range 25th-75th percentile) or mean (± standard deviation), as appropriate. CIS: clinically isolated syndrome, DMT: disease-modifying treatment, EDSS: Expanded Disability Status Scale, Gd: Gadolinium, FU: follow-up, NfL: Neurofilament light chain, No: Number, OCB: Oligoclonal Bands, RRMS: relapsing-remitting multiple sclerosis, SPMS: secondary progressive MS.