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. 2021 Sep 21;97(12):e1243–e1252. doi: 10.1212/WNL.0000000000012512

Figure 1. Association Between Baseline Plasma CRP and MMSE and CDR-SB Scores and CSF Biomarkers (t-Tau and p-Tau) Among Participants With MCI and AD Dementia Across 3 APOE Genotypes.

Figure 1

Because of imbalanced numbers of cognitive normal (CN) controls in each APOE group in Table 1, we excluded CN from the scatterplots. Participants with mild cognitive impairment (MCI) (n = 396) or Alzheimer Disease (AD) dementia (n = 112) were divided into 3 groups based on APOE genotypes: 0 APOE ε4 alleles (APOE ε4 = 0), 1 APOE ε4 allele (APOE ε4 = 1), and 2 APOE ε4 alleles (APOE ε4 = 2). Relationships between baseline plasma C-reactive protein (CRP) and trajectory cognitive tests or CSF AD biomarkers at baseline, 12 months, and 24 months were examined. Associations between baseline CRP and Mini-Mental State Examination (MMSE) scores (A), Clinical Dementia Rating Sum of Boxes (CDR-SB) score (B), CFS total tau (t-Tau) (C), and CFS phosphorylated tau (p-Tau) (D) are shown by using scatterplots with a linear regression line with 95% confidence bands (shaded area), the Pearson coefficient of correlation, and its p value.