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. 2020 Aug 27;106(10):2624–2632. doi: 10.3324/haematol.2020.256313

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Copyright© 2021 Ferrata Storti Foundation

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Figure 2. — Cdk6^Δ/Δ mice are anemic with compensatory upregulation of erythrocytes in the bone marrow. Analysis was performed 3 weeks post final polyinosinic– polycytidylic acid (poly(I:C)) injection. (A) Number of red blood cells (RBC) in peripheral blood (n≥12 for each group (Cdk4^Δ/Δ; Cdk6^Δ/Δ; Cdk4/6^fl/fl). (B) Percentage of Ter119⁺ cells in bone marrow quantified by flow cytometry (Cdk4^Δ/Δ; Cdk6^Δ/Δ; Cdk4/6^fl/fl, n≥7/genotype). (C) Gating strategy and representative flow cytometry pseudocolour plots for (D) quantification of erythroid development in the bone marrow (BM) based on CD71 and Ter119 expression from R1 to R4 (Cdk4^Δ/Δ; Cdk6^Δ/Δ; Cdk4/6^fl/fl, n≥8/genotype). All comparisons were done with one-way ANOVA followed by Tukey's Multiple Comparison Test, *P≤0.05, **P≤0.01, ***P≤0.001, ****P≤0.0001.