Table 2.
Trauma/PTSD status regression coefficients and standard errors from linear mixed models predicting log aldosterone (n=521)
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | |
|---|---|---|---|---|---|
| Time, Age, and Trauma/PTSD Fixed Effects |
Time, Age, and Trauma/PTSD × Time Fixed Effects |
Time, Age, and Trauma/PTSD with Covariates |
Time, Age, and Trauma/PTSD with Covariates and Pathway Variables |
Time, Age, and Trauma/PTSD with Covariates, Pathway Variables and Depression |
|
| β (SE) | β (SE) | β (SE) | β (SE) | β (SE) | |
| Fixed Effects | |||||
| Time | −0.01 (0.002)*** | −0.01 (0.003)+ | −0.01 (0.002)*** | −0.004 (0.003) | −0.004 (0.003) |
| Age at draw 1 Trauma/PTSD | −0.01 (0.003)*** | −0.01 (0.003)*** | −0.01 (0.003)** | −0.01 (0.004)* | −0.01 (0.004)* |
| No trauma | Reference | Reference | Reference | Reference | Reference |
| Trauma/no PTSD | −0.04 (0.04) | −0.02 (0.04) | −0.04 (0.04) | −0.04 (0.04) | −0.04 (0.04) |
| Chronic PTSD | −0.08 (0.04)* | −0.07 (0.04)+ | −0.08 (0.04)* | −0.09 (0.04)* | −0.09 (0.04)* |
| Trauma/PTSD x Time | |||||
| No trauma x Time | Reference | ||||
| Trauma/no PTSD x Time | −0.004 (0.004) | ||||
| Chronic PTSD x Time | −0.001 (0.004) | ||||
| Non-white | −0.05 (0.09) | −0.08 (0.09) | −0.08 (0.09) | ||
| Statin use | −0.01 (0.04) | −0.02 (0.04) | −0.02 (0.04) | ||
| Anti-hypertensive use | −0.05 (0.03) | −0.04 (0.03) | −0.04 (0.03) | ||
| Post-menopausal | −0.08 (0.04)* | −0.08 (0.04)* | |||
| BMI | 0.002 (0.003) | 0.002 (0.003) | |||
| Sodium | 0.00003 (0.00002)+ | 0.00003 (0.00002)+ | |||
| Physical activity <1/wk | Reference | Reference | |||
| Physical activity 1/wk | 0.09 (0.04)* | 0.09 (0.04)* | |||
| Physical activity 2-3/wk | 0.01 (0.03) | 0.01 (0.03) | |||
| Physical activity 4+/wk | 0.03 (0.04) | 0.03 (0.04) | |||
| Depressive symptoms | 0.003 (0.02) | ||||
| Error Variance | |||||
| Level-1 | 0.10 (0.01)*** | 0.10 (0.01)*** | 0.10 (0.01)*** | 0.10 (0.01)*** | 0.10 (0.01)*** |
| Intercept | 0.06 (0.01)*** | 0.06 (0.01)*** | 0.06 (0.01)*** | 0.06 (0.01)*** | 0.06 (0.01)*** |
| Time | 0.0003 (0.0001)** | 0.0003 (0.0001)** | 0.0003 (0.0001)** | 0.0003 (0.0001)** | 0.0003 (0.0001)** |
| Model Fit | |||||
| BIC | 1196.0 | 1213.6 | 1205.8 | 1241.6 | 1248.1 |
Notes. PTSD=posttraumatic stress disorder. Aldosterone was log-transformed pg/mL. Time=years since draw 1. All models adjust for age. Covariates are race/ethnicity (non-white versus white [reference]), statin use (versus non-use [reference]), and anti-hypertensive use (versus non-use [reference]). Pathway variables are post-menopausal status (versus pre-menopausal [reference]), BMI, sodium intake, and physical activity. Age, BMI, and sodium intake were grand-mean centered; depressive symptoms were standardized (mean=0, SD=1). Covariates (besides race/ethnicity), pathway variables and depression were time-updated to reflect values at draws 1 and 2. BIC= Bayesian information criterion. Smaller BIC indicates better model fit.
p<.10
p<.05
p<.01
p<.0001