Table 2.
DE miRNAs identified by microarray analysis in the screening phase.
| miRNA ID | MIMATID | Sequence | FC | P | FDR |
|---|---|---|---|---|---|
| hsa-miR-653-5p | MIMAT0003328 | guguugaaacaaucucuacug | 24.544 | 0.0005 | 0.18047 |
| hsa-miR-224-5p | MIMAT0000281 | ucaagucacuagugguuccguuuag | 20.148 | 0.0027 | 0.18047 |
| hsa-miR-206 | MIMAT0000462 | uggaauguaaggaagugugugg | 20.056 | 0.0037 | 0.18047 |
| hsa-miR-558 | MIMAT0003222 | ugagcugcuguaccaaaau | 19.013 | 0.0072 | 0.23381 |
| hsa-miR-573 | MIMAT0003238 | cugaagugauguguaacugaucag | 18.562 | 0.0222 | 0.34292 |
| hsa-miR-593 | MIMAT0003261 | aggcaccagccaggcauugcucagc | 17.143 | 0.0433 | 0.48152 |
| hsa-miR-425-3p | MIMAT0001343 | aucgggaaugucguguccgccc | 16.772 | 0.0133 | 0.30151 |
| hsa-miR-189 | MIMAT0000079 | ugccuacugagcugauaucagu | 15.837 | 0.0144 | 0.30151 |
| hsa-miR-525* | MIMAT0002839 | gaaggcgcuucccuuuagagcg | 14.999 | 0.0152 | 0.21726 |
| hsa-miR-200° | MIMAT0000682 | uaacacugucugguaacgaugu | 14.419 | 0.0055 | 0.34292 |
| ebv-miR-BHRF1-2* | MIMAT0000996 | aaauucuguugcagcagauagc | 14.385 | 0.0229 | 0.30112 |
| hsa-miR-601 | MIMAT0003269 | uggucuaggauuguuggaggag | 14.341 | 0.0100 | 0.21726 |
| hsa-miR-100 | MIMAT0000098 | aacccguagauccgaacuugug | 14.236 | 0.0054 | 0.35404 |
| hsa-miR-608 | MIMAT0003276 | aggggugguguugggacagcuccgu | 14.009 | 0.0245 | 0.45757 |
| hsa-miR-569 | MIMAT0003234 | aguuaaugaauccuggaaagu | 13.756 | 0.0399 | 0.34292 |
| ebv-miR-BART1-5p | MIMAT0000999 | ucuuaguggaagugacgugcugug | 13.104 | 0.0217 | 0.44399 |
| ebv-miR-BART14-3p | MIMAT0003426 | uaaaugcugcaguaguagggau | 11.894 | 0.0376 | 0.30791 |
| hsa-miR-376a | MIMAT0000729 | aucauagaggaaaauccacgu | 11.229 | 0.0166 | 0.41419 |
| hsa-miR-627 | MIMAT0003296 | gugagucucuaagaaaagagga | 10.759 | 0.0329 | 0.30151 |
| hsa-miR-302b | MIMAT0000715 | uaagugcuuccauguuuuaguag | -11.783 | 0.0449 | 0.48519 |
| hsa-miR-98 | MIMAT0000096 | ugagguaguaaguuguauuguu | -12.594 | 0.0329 | 0.41419 |
| hsa-miR-520e | MIMAT0002825 | aaagugcuuccuuuuugaggg | -14.332 | 0.0287 | 0.39922 |
| ebv-miR-BART6-3p | MIMAT0003415 | cggggaucggacuagccuuaga | -16.170 | 0.0069 | 0.23381 |
| hsa-miR-340 | MIMAT0004692 | uuauaaagcaaugagacugauu | -16.206 | 0.0363 | 0.44212 |
| hsa-miR-566 | MIMAT0003230 | gggcgccugugaucccaac | -16.358 | 0.0155 | 0.30151 |
| kshv-miR-K12-7 | MIMAT0002187 | ugaucccauguugcuggcgc | -16.632 | 0.0222 | 0.34292 |
| hsa-miR-423 | MIMAT0001340 | agcucggucugaggccccucagu | -17.271 | 0.0330 | 0.41419 |
| kshv-miR-K12-9 | MIMAT0002185 | cuggguauacgcagcugcguaa | -18.083 | 0.0187 | 0.33113 |
| hsa-miR-519e* | MIMAT0002828 | uucuccaaaagggagcacuuuc | -18.331 | 0.0130 | 0.30151 |
| hsa-miR-432 | MIMAT0002814 | ucuuggaguaggucauugggugg | -18.483 | 0.0144 | 0.30151 |
| hsa-miR-31 | MIMAT0000089 | aggcaagaugcuggcauagcu | -19.111 | 0.0111 | 0.30151 |
| kshv-miR-K12-1 | MIMAT0002182 | auuacaggaaacuggguguaagc | -20.371 | 0.0026 | 0.18047 |
| hsa-miR-411-5p | MIMAT0003329 | uaguagaccguauagcguacg | -21.903 | 0.0013 | 0.18047 |
| hsa-miR-187-3p | MIMAT0000262 | ucgugucuuguguugcagccgg | -21.927 | 0.0037 | 0.18047 |
| hsa-miR-27a-3p | MIMAT0000084 | uucacaguggcuaaguuccgc | -22.675 | 0.0034 | 0.18047 |
| hsa-miR-600 | MIMAT0003268 | acuuacagacaagagccuugcuc | -23.197 | 0.0033 | 0.18047 |
Human miRNAs (indicated by “hsa” prefix) are in bold while viral ones are in italic, P values were calculated by two-tailed Student T test. MIMATID=unique mature miRNA accession number. FC=normalized expression fold change values in log2 scale. P=Limma (Linear models for Microarray Data) differential expression t-test p-value. n=34 (16 BS patients vs 18 HC). FDR= False Discovery Rate false discovery rate (determined according to the Benjamini-Hoechberg's method).