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. 2021 Oct 8;9:e12262. doi: 10.7717/peerj.12262

Figure 3. WIN reduces inflammatory markers and viral toxicity in SARS-CoV-2-infected hiPSC-CMs.

Figure 3

Levels of IL-6 (A), IL-8 (B), TNF-α (C), and (D) release of lactate dehydrogenase (LDH) from MOCK and SARS-CoV-2-infected hiPSC-CM, treated or not with one μM WIN for 24 h, were analyzed at 24-, 48-and 72-h post-infection (h.p.i.). Cytokine levels were higher in SARS-CoV-2 compared with control (MOCK), and lower in SARS-CoV-2 WIN when compared with SARS-CoV-2. LDH release-absorbance levels relative to MOCK were higher in SARS-CoV-2 compared with SARS-CoV-2 WIN. Data represent means and standard errors of the means (SEM) from three independent experiments from one cell line. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.