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. 2021 Jun 29;46(12):2170–2179. doi: 10.1038/s41386-021-01056-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Schematic diagram of treatment regimen, starting at 5 months of age (online version in colour). B Whereas sHFS triggered robust LTP in wild-type rats pretreated 1 month previously with CORT (WT CORT 10), the same pretreatment in transgenic rats strongly inhibited LTP (TG CORT 10). Six-day i.p. treatment with Mcc950 (16 mg/kg/day) reversed the LTP deficit in transgenic rats (TG CORT 10 MCC950). An arrowhead indicates the time point of sHFS application. Inserts show representative EPSP traces at the times indicated. Calibration bars: Vertical, 1 mV, horizontal 10 ms. LTP magnitude was determined during the last 10 min. Statistical summary is in the right hand panel. Number of animals per group is shown on the bar. *p < 0.05 (one-way ANOVA followed by Bonferroni’s multiple comparison test); ^#p < 0. 05, ^##p < 0.01 compared with pre-sHFS baseline (paired t test). Values are the mean ± S.E.M. % pre-HFS baseline EPSP amplitude.