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. 2021 Oct 12;10(10):67. doi: 10.1038/s41389-021-00356-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Analyses of TRPCs mRNA expression in adjacent normal tissues (n = 287) and colorectal tumor tissues (n = 1994) in the GENT2 dataset. B Protein expression of TRPC1 in colorectal tumor tissues (n = 98) and adjacent normal tissues (n = 13) from the local cohort were assessed by IHC. C TRPC1 expression in 13 paired colorectal cancer and adjacent normal tissues from the local cohort were assessed by IHC. D Analyses of the TRPC1 mRNA expression in different CRC tumor stage (n = 459) in the TCGA database. E Analyses of TRPC1 mRNA levels in primary colorectal tumors (n = 365) and metastasis tumors (n = 60) in the TCGA database. F Kaplan–Meier survival analysis of overall survival according to the TRPC1 mRNA expression in the TCGA database. High TRPC1 expression predicts poor overall survival in colorectal cancer. G Kaplan–Meier survival analysis of overall survival according to the TRPC1 mRNA expression in CRC patients with stage I/II or stage III/IV in the TCGA database. H Analyses of the TRPC1 protein expression in primary colorectal tumors (n = 61) and metastasis tumors (n = 37) in local cohort by IHC. I TRPC1 was frequently upregulated in CRC cell lines as determined by Western blot analysis (n = 3). **P < 0.01 vs. NCM460 group. **P < 0.01.