Figure 1. Tumor Necrosis Factor alpha-initiated signal transduction. The Tumor Necrosis Factor Receptor 1 is involved in the apoptotic pathway whereas Tumor Necrosis Factor Receptor 2 is anti-apoptotic through the Etk protein.

TNF: tumor necrosis factor; SODD: silencer of death domains; TNFR1: tumor necrosis factor receptor 1; TNFR2: tumor necrosis factor receptor 2; NF-kB: nuclear factor kappa B; MAP3K: mitogen-activated protein kinase kinase kinase; JNK: c-Jun N-terminal kinase