TABLE 1.
Demographic and Clinical Characteristics of the Study Patients (n = 438)
| Gender, n (%) | |
| Men | 99 (23%) |
| Women | 339 (77%) |
| Age (yr) | |
| Median [range]; mean ± SD | 51 [15-83]; 51.13 ± 12.28 |
| Karnofsky Performance Index before SRS (score) | |
| Median [range]; mean ± SD | 90 [50-100]; 85.31 ± 13.97 |
| Data not reported | 244 (56%) |
| Pre-SRS visual deficit, n (%) | |
| Yes | 257 (59%) |
| No | 181 (41%) |
| Other presenting symptoms, na | |
| Headache | 85 |
| Diplopia | 43 |
| Ptosis | 41 |
| Incidental | 35 |
| Seizure | 18 |
| Other | 62 |
| Duration of symptoms (mo) | |
| Median [range]; mean ± SD | 10 [0-240]; 19.60 ± 30.23 |
| Unknown or data not available | 71 (16%) |
| Pre-SRS endocrinopathy, n (%) | |
| None | 412 (94%) |
| Hypothyroidism | 15 (3%) |
| Estrogen/testosterone deficiency | 3 (1%) |
| Diabetes insipidus | 1 (0%) |
| Not reported | 7 (2%) |
| Nearest distance to the optic apparatus (mm) | |
| Median [range]; mean ± SD | 0 [0-2.3]; 0.36 ± 0.67 |
| In direct contact with optic pathway | 328 (75%) |
| Meningioma principal location, n (%) | |
| Clinoid | 191 (44%) |
| Tuberculum sella | 136 (31%) |
| Sphenoid wing | 31 (7%) |
| Planum sphenoidale | 17 (4%) |
| Clival/petroclival | 15 (3%) |
| Parasellar | 10 (2%) |
| Suprasellar | 8 (2%) |
| Intraorbital | 4 (1%) |
| Intrasellar | 2 (1%) |
| Optic sheath | 1 (0%) |
| Temporal pole | 1 (0%) |
| Frontobasal | 1 (0%) |
| Optic nerve sheath | 1 (0%) |
| Not specified/other | 8 (2%) |
| Other meningiomas, n (%) | 77 (8%) |
| Index meningioma surgery before SRS, n (%) | 153 (35%) |
| Number of prior resections, n (%) | |
| 1 | 121 (79%) |
| 2 | 28 (18%) |
| 3 | 3 (2%) |
| 4 | 1 (1%) |
| Type of prior resection, n (%) | |
| Gross total resection | 21 (14%) |
| Subtotal resection | 120 (79%) |
| Biopsy | 9 (6%) |
| Data not available | 2 (1%) |
| Interval between surgery and SRS (mo) | |
| Median [range]; mean ± SD | 9 [1-246]; 28.32 ± 44.57 |
| Meningioma WHO grade, n (%) | |
| I | 124 (28%) |
| II | 2 (1%) |
| No pre-SRS surgery or data not available | 312 (71%) |
| Histological type of index meningioma, n (%) | |
| Meningothelial | 30 (7%) |
| Transitional | 28 (6%) |
| Psammomatous | 10 (2%) |
| Fibroblastic | 5 (1%) |
| Mixed transitional and fibroblastic | 5 (1%) |
| Angiomatous | 1 (0.2%) |
| Microcystic | 1 (0.2%) |
| Secretory | 1 (0.2%) |
| Atypical | 1 (0.2%) |
| No pre-SRS surgery or data not available | 356 (81%) |
| Pre-SRS fractionated radiation therapy, n (%) | 10 (2%) |
| Pre-SRS radiation therapy dose (Gy) | |
| Median [range]; mean ± SD | 45 [13-60]; 40.42 ± 18.15 |
| Data not available | 4 (40%) |
| Pre-SRS radiation therapy number of fractions | |
| Median [range]; mean ± SD | 17 [1-30]; 15.67 ± 12.21 |
| Data not available | 4 (40%) |
SD, standard deviation.
aTotal number does not add up to 438 because some patients had more than 1 presenting symptom.