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Reagents and condition: i) a) SOCl2, reflux, 1 h; b) aq. 33 % NH3, CH3CN, rt, 1 h, 95 %; ii) CuBr, 1‐(4‐propoxyphenyl)ethan‐1‐one, Cs2CO3, dry DMSO, 110 °C, 8 h, 30 %; iii) POCl3, reflux, 3 h; iv) 2‐(diethylamino)ethan‐1‐ol or 1‐piperidinethaanol, NaH, dry THF, reflux, 1–3 h, 50–53 %.
