Table 2.
EtBr efflux inhibition (%) on SA‐1199B of compounds 8 b, 8 c, 12 c and 13 a at 50 μM. Evaluation of cell survival (%) of THP‐1 and A549 cell lines treated with 8 b, 8 c, 12 c and 13 a at 0.78 and 6.25 μg/mL.
|
Compd. |
EtBr efflux inhib. at 50 μM (±SD)[a] |
Cell survival (%)(±SD)[b] |
||
|---|---|---|---|---|
|
|
|
Compd. Concentration [μg/mL] |
THP‐1 cells |
A549 cells |
|
8 b |
78.4±10.2 |
0.78 |
90.6±27.8 |
116.8±7.7 |
|
6.25 |
90.1±5.3 |
136.3±8.1 |
||
|
8 c |
79.4±16.1 |
0.78 |
92.5±11.5 |
124.8±7.3 |
|
6.25 |
89.8±9.9 |
123.7±7.4 |
||
|
12 c |
66.7±7.8 |
0.78 |
101.4±12.9 |
116.8±6.11 |
|
6.25 |
84.9±9.4 |
116.2±4.7 |
||
|
13 a |
68.2±13.2 |
0.78 |
93.8±19.0 |
109.1±4.0 |
|
6.25 |
84.1±19.0 |
98.7±5.9 |
||
[a] SD, standard deviation; assays were conducted in triplicate performing two technical replicates for each biological replicate evaluated; [b] SD, assays were performed in biological and technical duplicate.