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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2021 Sep 2:ciab762. doi: 10.1093/cid/ciab762

Association of E484K spike protein mutation with SARS-CoV-2 infection in vaccinated persons---Maryland, January – May 2021

Kenneth A Feder 1,2,3,, Ami Patel 3, Venkata R Vepachedu 3,, Catherine Dominguez 3, Eric N Keller 3, Liore Klein 3, Curi Kim 3, Tim Blood 3, Judie Hyun 3, Thelonious W Williams 3, Katherine A Feldman 3, Heba H Mostafa 4, C Paul Morris 4,5, Jacques Ravel 6, Monique Duwell 3, David Blythe 3, Robert Myers 3
PMCID: PMC8522365  PMID: 34473242

Abstract

Among 9,048 people infected with SARS-CoV-2 between January-May, 2021 in Maryland, in regression-adjusted analysis, SARS-CoV-2 viruses carrying the spike protein mutation E484K were disproportionately prevalent among persons infected after full vaccination against COVID-19 as compared to infected persons who were not fully vaccinated (aOR 1.96, 95% CI, 1.36 to 2.83).

Keywords: COVID-19, COVID-19 vaccine effectiveness, SARS-CoV-2, variants of concern, sequencing, genomic surveillance, E484K, L452R, B.1.526, B.1.351, R.1, B.1.526.1, B.1.429, B.1

Supplementary Material

ciab762_suppl_Supplementary_Figure_S1
ciab762_suppl_Supplementary_Figure_S2
ciab762_suppl_Supplementary_Materials

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

ciab762_suppl_Supplementary_Figure_S1
ciab762_suppl_Supplementary_Figure_S2
ciab762_suppl_Supplementary_Materials

Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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