Table 3.

General and sex-specific HRs for the relationship between percentage of target dose and all-cause mortality stratified by HF subtype

	All HF subtypes		HFrEF		HFpEF
	Crude HR (95% CI)	Adjusted HR (95% CI)	Crude HR (95% CI)	Adjusted HR (95% CI)	Crude HR (95% CI)	Adjusted HR (95% CI)
Whole cohort
ACEI/ARB
<50% of target dose	1.07 (0.81 to 1.42) p=0.62	1.01 (0.76 to 1.33) p=0.96	0.71 (0.47 to 1.07) p=0.10	0.63 (0.42 to 0.96) p=0.03	0.92 (0.50 to 1.68) p=0.79	1.02 (0.57 to 1.84) p=0.94
≥50% of target dose (ref)	1	1	1	1	1	1
Beta blockers
<50% of target dose	1.00 (0.75 to 1.35) p=0.97	1.05 (0.78 to 1.41) p=0.75	0.91 (0.57 to 1.45) p=0.68	0.99 (0.62 to 1.59) p=0.96	1.17 (0.62 to 2.21) p=0.63	1.27 (0.69 to 2.35) p=0.44
≥50% of target dose (ref)	1	1	1	1	1	1
Women
ACEI/ARB
<50% of target dose	1.07 (0.70 to 1.63) p=0.76	1.05 (0.69 to 1.60) p=0.82	0.54 (0.28 to 1.03) p=0.06	0.49 (0.25 to 0.99) p=0.05	0.70 (0.30 to 1.64) p=0.41	0.75 (0.32 to 1.73) p=0.50
≥50% of target dose (ref)	1	1	1	1	1	1
Beta blockers
<50% of target dose	1.09 (0.71 to 1.66) p=0.69	1.10 (0.72 to 1.68) p=0.66	0.96 (0.47 to 1.95) p=0.92	1.06 (0.51 to 2.20) p=0.88	1.54 (0.72 to 3.29) p=0.27	1.62 (0.77 to 3.40) p=0.21
≥50% of target dose (ref)	1	1	1	1	1	1
Men
ACEI/ARB
<50% of target dose	1.10 (0.75 to 1.59) p=0.63	1.00 (0.69 to 1.44) p=0.98	0.88 (0.52 to 1.49) p=0.64	0.76 (0.45 to 1.28) p=0.30	1.35 (0.57 to 3.21) p=0.50	1.48 (0.64 to 3.44) p=0.36
≥50% of target dose (ref)	1	1	1	1	1	1
Beta blockers
<50% of target dose	0.93 (0.62 to 1.41) p=0.74	1.00 (0.67 to 1.51) p=0.98	0.88 (0.47 to 1.63) p=0.68	0.95 (0.51 to 1.76) p=0.86	0.62 (0.19 to 2.09) p=0.44	0.75 (0.24 to 2.29) p=0.61
≥50% of target dose (ref)	1	1	1	1	1	1

ACEI, ACE inhibitor; AR, angiotensin II receptor; ARB, angiotensin-receptor blocker; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; ref, reference.