Table 3.

MTD of D-melittin and D-melittin micelles. Normal mice were injected with a range of concentrations and sacrificed when euthanasia criteria were met. While mice survived following peptide injection at 4 mg/kg, this dose was poorly tolerated. The MTD of free peptide and micelles was determined to be 2 mg/kg and 20 mg peptide/kg, respectively. For DMM, the dose is expressed in regards to peptide amount in the formulation. (n = 4 mice/group)

D-melittin free peptide		DMM
Dose	Deaths	Dose	Deaths
2 mg/kg	0/4	10 mg/kg	0/4
4 mg/kg	0/4	20 mg/kg	0/4
6 mg/kg	4/4	30 mg/kg	2/4
8 mg/kg	4/4	40 mg/kg	4/4
MTD	2 mg/kg	MTD	20 mg/kg