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. 2021 Oct 8;10:e69480. doi: 10.7554/eLife.69480

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© 2021, Hwang et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 6. — (A) Comparison lesion sites associated with multi-domain impairment are located in the lateral frontal and posterior parietal regions. (B) Frontal and parietal regions exhibit strong connector hub properties (measured by participation coefficient [PC]). (C) Kernel density plot of voxel-wise PC values from comparison lesion sites associated with multi-domain and single-domain impairment. Voxel-wise PC values were significantly higher for multi-domain lesion sites. The y-axis was scaled so area under the curve is summated to one. (D) Comparing the distribution of PC values in comparison and thalamic lesion sites. (E) Comparing multiple-domain impairment score between thalamic and expanded comparison patients with multi-domain impairment.