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. Author manuscript; available in PMC: 2022 Oct 14.
Published in final edited form as: Cell. 2021 Oct 6;184(21):5405–5418.e16. doi: 10.1016/j.cell.2021.09.011

Figure 1. A screen for a selective anti-Borreliella compound.

Figure 1.

A. Actinomycete strains were fermented in liquid culture. Concentrated culture supernatants were screened against B. burgdorferi Bb1286 expressing GFP, and against S. aureus HG003. Extracts showing specific activity against B. burgdorferi were fractionated by HPLC, and their activity was determined by bioassay. After LCMS and NMR analysis, the active compound from one of the producers was determined to be hygromycin A. B. MIC of hygromycin A against spirochaetes, human pathogens and commensals. Phylogenetic tree shows similarities between strains.