Table 5.
Spirometry and gas transfer testing results in patients at follow-up and controls.
| COVID-19, 2-3m | COVID-19, 6m | Controls |
P-values |
|||
|---|---|---|---|---|---|---|
| 2-3m vs Controls | 6m vs Controls | 2-3m vs 6m | ||||
| Spirometry | ||||||
| FVC, % predicted | 108·3 (22·8) | 119·2 (22·0) | 131·4 (21·8) | <0·0001 | 0·024 | <0·0001a |
| <80% | 7/56 (12·5%) | 0/46 (0·0%) | 0/28 (0·0%) | 0·090b | ·· | 0·016c |
| FEV 1, % predicted | 101·4 (19·7) | 110·7 (18·6) | 118·7 (22·1) | 0·0004 | 0·10 | <0·0001a |
| <80% | 6/56 (10·7%) | 1/46 (2·2%) | 1/28 (3·6%) | 0·42b | 1·00b | 0·063c |
| FEV1/FVC | 0·77 (0·73 - 0·80) | 0·76 (0·73 - 0·80) | 0·75 (0·70 - 0·78) | 0·027d | 0·24 | 0·051a |
| Peak expiratory flow, % predicted | 105·7 (27·7) | 108·8 (21·7) | 114·5 (24·7) | 0·16 | 0·31 | 0·74a |
| Gas Transfer | ||||||
| DLCO, % of predicted | ·· | 80·9 (16·9) | ·· | ·· | ·· | ·· |
| <80% | ·· | 24/46 (52·2%) | ·· | ·· | ·· | ·· |
| KCO, % of predicted | ·· | 101·8 (18·2) | ·· | ·· | ·· | ·· |
| <80% | ·· | 6/46 (13·0%) | ·· | ·· | ·· | ·· |
| Va, % of predicted | ·· | 79·9 (14·7) | ·· | ·· | ·· | ·· |
| <80% | ·· | 24/46 (52·2%) | ·· | ·· | ·· | ·· |
Data are median (IQR) for non-parametric data, mean (SD) for parametric data, and n/N (%), where N is the total number of participants with available data. P-values from independent t-test, paired t-test (a), Fisher's exact test (b), McNemar test (c) or Mann-Whitney U test (d), with bold values highlighting statistical significance. 2-3m = Two to three months. 6m = Six months. FVC = Forced vital capacity. FEV1 = Forced expiratory volume in 1 second. DLCO = Diffusion capacity for carbon monoxide. KCO = Transfer coefficient for carbon monoxide. Va = Alveolar volume.