Abstract
Proteolysis‐Targeting Chimera Technology
In article number 2102555, Hong‐yu Li, Haojie Huang, and co‐workers demonstrate a new approach, oligonucleotide‐based proteolysis‐targeting chimera (O'PROTAC), to degrade “undruggable” transcriptional factors (TFs) via the ubiquitin‐proteasome system. O'PROTAC is designed by employing the TF‐uniquely‐recognized DNA sequence as natural “ligand”. The programmability of O'PROTAC makes it an attractive arsenal to target TFs for treatment of diseases including cancer.
