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. 2021 Oct 19;9(10):1498. doi: 10.3390/biomedicines9101498

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The implication of mTORC2/RICTOR in the resistance of melanoma to targeted therapies in cells grown as spheroids. (A,B) A375 parental and resistant cell lines were grown as spheroids and treated with DMSO, Vemurafenib (10 μM), OSI-027 (3 μM), or the combination of both for 10 days and counted. Pictures were taken after 10 days of treatment; scale bar represents 1000 μm. Graphs represent the mean ± s.d. of an experiment in triplicate (similar results were obtained in three independent experiments).