Table 2.

The parameters characterized the effects of alkaloids on the physical properties of lipid bilayers: T_m—the main transition temperature of DPPG/CHOL (90/10 mol%); T_1/2—the half-width of the main peak in the presence of 400 μM of alkaloids (40 μM of tabersonine); Δφ_b(max)—the maximum changes in the boundary potential of DOPG/CHOL (80/20 mol%) membranes.

Alkaloid	Tm, °C	T1/2, °C	Δφb(max), mV
control	40.4 ± 0.0	0.8 ± 0.0	–
colchicine	40.4 ± 0.0	0.8 ± 0.0	−24 ± 6
cotinine	40.4 ± 0.0	0.8 ± 0.0	−7 ± 3
1,7-dimethylxanthine	40.4 ± 0.0	0.8 ± 0.0	−5 ± 2
capsaicin	38.3 ± 0.2 *	2.0 ± 0.1 *	−70 ± 7
synephrine	40.1 ± 0.1 *	1.2 ± 0.1 *	−25 ± 3
3-isobutyl-1-methylxanthine	39.9 ± 0.2 *	1.2 ± 0.1 *	−18 ± 4
piperine	39.5 ± 0.3 *	1.5 ± 0.2 *	−39 ± 8
tabersonine	38.5 ± 0.2 *	1.9 ± 0.2 *	58 ± 9
hordenine	39.7 ± 0.2 *	1.2 ± 0.1 *	8 ± 3
lupinine	39.7 ± 0.1 *	1.5 ± 0.2 *	−30 ± 3

*—p ≤ 0.01 (Mann–Whitney–Wilcoxon’s test, control vs. alkaloid).