Table 5.
MiRNA levels in postmortem brains from patients with SCZ.
| Brain Region | Reference | Method | miR-29a/b/c-3p | miR-132-3p | miR-137-3p |
|---|---|---|---|---|---|
| DLPFC (BA9) | Perkins et al., 2007 [6] | Microarray, RT-qPCR (miR-29b) |
Decreased (a/b/c) | NS | NS |
| Beveridge et al., 2010 [7] | Microarray | Increased (c) NS (a/b) |
NS | NR | |
| Moreau et al., 2011 [8] | RT-qPCR | NS | NS | NE | |
| DLPFC (BA46) | Kim et al., 2010 [9] | RT-qPCR | NS | Increased | NS |
| Miller et al., 2012 [10] | Microarray RT-qPCR (miR-132-3p) |
NS | Decreased | NS | |
| Hu et al., 2019 [11] | Small RNA-seq | NS | NS | NS | |
| STG (BA22) | Beveridge et al., 2008 [12] | Microarray | NS | NS | NE |
| Beveridge et al., 2010 [7] | Microarray | NS | NS | NR | |
| Amygdala | Liu et al., 2018 [13] | Small RNA-seq | NS | Decreased | NS |
(a/b/c) indicates specific miR-29 variant reported in each study. Abbreviations: BA, Brodmann’s area; DLPFC, dorsolateral prefrontal cortex; NE, not examined; NR, not reported (unclear if NE or NS); NS, not significant; STG, superior temporal gyrus.