Figure 5.

Supplemental ASTX inhibits oxidative stress, DNA damage, and expression of inflammatory cytokines in the periodontium of STZ-induced diabetic mice. Expression levels of (A) 8-OHdG, (B) γ-H2AX, and (C) IL-1β in periodontal tissue sections including the region of maxillary molars (M1 to M3) were evaluated by IHC assay using their specific antibodies 60 days after hyperglycemia induction (200× magnification). Bar = 100 μm. A representative result from five different samples per each experiment is shown.