Table 2.
Percentage abundances of fecal microbiota compared between baseline and prebiotics in the per protocol, remission at baseline (Simple Clinical Colitis Activity Score (SCCAI) score ≤ 2), and not in remission at baseline (SCCAI score > 2) populations in a 6-week open-label study of GOS prebiotics in active ulcerative colitis. The taxa with the top 10 Z-scores are presented for each group comparison.
| Mean (SD) | ||||||
|---|---|---|---|---|---|---|
| Per Protocol Population (n = 13) | Baseline | Prebiotic | Z-Score | p-Value * | ||
| p__Firmicutes_g__Dialister | 3.39 | (3.84) | 1.83 | (1.88) | −2.411 b | 0.016 |
| p__Firmicutes_g__Anaerostipes | 0.17 | (0.17) | 0.55 | (0.79) | −2.040 c | 0.041 |
| p__Firmicutes_g__Oscillospira | 3.81 | (3.03) | 2.80 | (2.58) | −1.992 b | 0.046 |
| p__Firmicutes_f_[Mogibacteriaceae] | 0.38 | (0.43) | 0.24 | (0.24) | −1.883 b | 0.06 |
| p__Firmicutes_g__Dorea | 1.24 | (0.79) | 1.56 | (0.91) | −1.852 c | 0.064 |
| p__Bacteroidetes_g__Paraprevotella | 0.04 | (0.08) | 0.14 | (0.27) | −1.826 c | 0.068 |
| p__Proteobacteria_g__Haemophilus | 2.86 | (9.53) | 0.26 | (0.74) | −1.782 b | 0.075 |
| p__Firmicutes_f__Erysipelotrichaceae | 0.86 | (1.54) | 1.58 | (3.20) | −1.642 c | 0.101 |
| p__Actinobacteria_g__Corynebacterium | 0.00 | (0.00) | 0.01 | (0.04) | −1.604 c | 0.109 |
| p__Firmicutes_g__Anaerotruncus | 0.03 | (0.05) | 0.02 | (0.04) | −1.599 b | 0.11 |
| Patients in remission at baseline (SCCAI≤2) (n = 6) | ||||||
| p__Firmicutes_ f__Christensenellaceae | 0.58 | (1.27) | 1.25 | (2.47) | −2.023 c | 0.043 |
| p__Actinobacteria_g__Bifidobacterium | 1.05 | (1.27) | 3.99 | (5.37) | −1.992 c | 0.046 |
| p__Firmicutes_g__Anaerostipes | 0.17 | (0.14) | 0.49 | (0.44) | −1.782 c | 0.075 |
| p__Firmicutes_f__[Mogibacteriaceae] | 0.24 | (0.30) | 0.18 | (0.29) | −1.753 b | 0.08 |
| p__Bacteroidetes_g__Prevotella | 2.46 | (3.81) | 0.43 | (0.93) | −1.604 b | 0.109 |
| p__Firmicutes_g__Holdemania | 0.03 | (0.04) | 0.01 | (0.02) | −1.604 b | 0.109 |
| p__Firmicutes_f__Ruminococcaceae | 3.66 | (4.56) | 6.88 | (7.66) | −1.572 c | 0.116 |
| p__Firmicutes_g__Dorea | 0.93 | (0.62) | 1.49 | (0.88) | −1.572 c | 0.116 |
| p__Firmicutes_g__Dialister | 3.25 | (5.04) | 1.72 | (1.88) | −1.363 b | 0.173 |
| p__Actinobacteria_g__Slackia | 0.03 | (0.08) | 0.05 | (0.08) | −1.342 c | 0.18 |
| Patients not in remission at baseline (SCCAI>2) (n = 7) | ||||||
| p__Firmicutes_g__Dialister | 3.50 | (2.87) | 1.92 | (2.02) | −2.028 b | 0.043 |
| p__Firmicutes_g__Roseburia | 3.27 | (2.35) | 5.86 | (3.78) | −1.859 c | 0.063 |
| p__Firmicutes_g__Blautia | 2.74 | (1.83) | 4.60 | (3.38) | −1.859 c | 0.063 |
| p__Proteobacteria_g__Sutterella | 0.22 | (0.20) | 0.41 | (0.28) | −1.859 c | 0.063 |
| p__Firmicutes_g__Oxobacter | 0.06 | (0.08) | 0.02 | (0.04) | −1.826 b | 0.068 |
| p__Cyanobacteria_o__Streptophyta | 0.03 | (0.04) | 0.01 | (0.03) | −1.753 b | 0.08 |
| p__Proteobacteria_g__Bilophila | 0.07 | (0.08) | 0.22 | (0.22) | −1.753 c | 0.08 |
| p__Firmicutes_g__Oscillospira | 3.81 | (3.11) | 2.47 | (1.86) | −1.690 b | 0.091 |
| p__Firmicutes_g__Anaerofilum | 0.01 | (0.01) | 0.00 | (0.01) | −1.604 b | 0.109 |
| p__Proteobacteria_g__Haemophilus | 5.03 | (13.02) | 0.41 | (1.02) | −1.521 b | 0.128 |
* p values for symptoms are the result of a Wilcoxon signed-rank test, p was considered statistically significant if <0.05 and values reaching this threshold are marked in bold. p = phylum; o = order; f = family; g = genus; b = based on positive ranks; c = based on negative ranks.