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. 2021 Sep 24;13(10):1552. doi: 10.3390/pharmaceutics13101552

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Evaluation of treatments and their adverse effects over C57BL/6J mice with melanoma. (A) Variation of body weight (B) Analysis of feed intake. (C) Weight of the organs (liver, spleen, kidneys, lung) and tumor region. (D) Kaplan–Meier survival curves for the different treated groups: naive, positive control (PBS group), positive control, DTX_T-HYD IT and nanohybrid hydrogel groups HGel-LDC TP, HGel-NLC_DTX TP, HGel-NLC_DTX-LDC TP and NLC_DTX IT + HGel-LDC TP. Statistical analysis: Two-Way ANOVA post-hoc Bonferroni, *** p < 0.001; n = 5.