Table 4.

Values estimated by micro-PET/CT analysis of the percent ratio of the maximum or mean injected dose between the tumor region and the adjacent tissue (%ID^[T/BG]_Max and %ID^[T/BG]_Mean), or liver (%ID^[T/L]_Max and %ID^[T/L]_Mean); tumor metabolic volume (MTV) and total lesion glycolysis (TLG). The anatomical volume of the tumor (TV) measured with an external caliper is also given.

	Micro-PET/CT						Caliper
Formulations	%ID[T/BG]Max	%ID[T/BG]Mean	%ID[T/L]Max	%ID[T/L]Mean	MTV	TLG	TV (mm³)
Positive Control	9.169	11.336	2.812	2.570	0.633	1.558	3741.68
DTXT-HYD IT	2.012	3.354	1.457	1.795	0.051	0.105	41.87
HGel-LDC TP	8.350	8.512	2.498	2.209	0.199	0.288	752.33
HGel-NLCDTX TP	5.205	4.752	1.060	0.731	0.728	1.287	544.01
HGel-NLCDTX-LDC TP	3.641	4.129	0.518	0.390	0.034	0.095	155.23
NLCDTX IT + HGel-LDC TP	1.230	1.806	0.410	0.423	0.012	0.011	42.60

Notations: T: tumor; BG: normal adjacent tissue (background); L: liver. %ID^[T/BG]_Max = $\frac{\%\mathrm{ID}\mathrm{TMa}x }{\%I\mathrm{D}\mathrm{BGMax}}$; %ID^[T/BG]_Mean = $\frac{\%\mathrm{ID}\mathrm{TMean} }{\%\mathrm{ID}\mathrm{BGMean}}$; %ID^[T/L]_Max = $\frac{\%\mathrm{ID}\mathrm{TMax} }{\%\mathrm{ID}\mathrm{LMax}}$; %ID^[T/L]_Mean = $\frac{\%\mathrm{ID}\mathrm{TMean} }{\%\mathrm{ID}\mathrm{LMean}}$. The raw values of%IDMax and%IDMean in tumor, adjacent tissue and liver are shown in Table S3.