Table 1.
The composition and physicochemical characterization of different RES-loaded bilosomes.
| Formula | Molar Ratio of SPC/SDC/CH | Number of Extrusion Cycles | Drug Conc. (mg/mL) | pH | %EE | Particle Size (nm) | PDI | Zeta Potential (mV) |
|---|---|---|---|---|---|---|---|---|
| B1 | 4:1:0 | 1 | 5 | 7.4 | 16.3 ± 1.56 | 254 ± 1.47 | 0.621 ± 0.011 | −31.0 ± 1.65 |
| B2 | 4:1:0 | 2 | 5 | 7.4 | 19.3 ± 1.20 | 218 ± 1.95 | 0.745 ± 0.012 | −29.0 ± 2.06 |
| B3 | 4:1:0 | 3 | 5 | 7.4 | 29.3 ± 2.05 | 198 ± 1.45 | 0.512 ± 0.016 | −26.6 ± 1.08 |
| B4 | 4:1:0 | 4 | 5 | 7.4 | 21.2 ± 0.98 | 210 ± 2.05 | 0.806 ± 0024 | −27.2 ± 1.45 |
| B5 | 4:1:0 | 3 | 10 | 7.4 | 67.0 ± 1.56 | 316 ± 1.87 | 0.330 ± 0.022 | −28.0 ± 1.52 |
| B6 | 4:1:0 | 3 | 20 | 7.4 | 54.0 ± 2.52 | 375 ± 2.08 | 0.723 ± 0.031 | −27.0 ± 2.23 |
| B7 | 4:1:0 | 3 | 30 | 7.4 | 42.0 ± 1.96 | 381 ± 2.60 | 0.780 ± 0.018 | −26.4 ± 1.78 |
| B8 | 4:1:0 | 3 | 10 | 3 | 72.3 ± 1.87 | 265 ± 1.58 | 0.18 ± 0.013 | −35.5 ± 2.80 |
| B9 | 4:1:1 | 3 | 10 | 3 | 76.2 ± 1.36 | 189 ± 2.14 | 0.116 ± 0.015 | −31.2 ± 2.2 |
SPC: LIPOID S100 (soybean phosphatidylcholine), SDC: sodium deoxycholate and CH: Cholesterol, %EE: entrapment efficiency, PDI: polydispersity index. Each result is the mean of three determinations ± SD.